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Haifei Shi

Biographical Information

Obesity is a major health problem exacerbating many other disorders and is a health risk in its own right. Our research focuses on the neural and hormonal control of energy metabolism, and the mechanisms of pathological conditions of obesity and related diseases including cancer. Males and females adopt fundamentally different strategies to maintain energy balance. This is an important issue for understanding and treating obesity and related disorders, which has not received enough scientific attention. The overall research goal is to investigate effects of sex hormones in the regulation of energy metabolism. Graduate and undergraduate students in my laboratory use physiological, biochemical, and molecular techniques in their projects.

Selected Publications

• Pence S, LaRussa Z, Shen Z, Liu M, Coschigano KT, Shi H, Lo CC (2021). Central Apolipoprotein A-IV stimulates thermogenesis in brown adipose tissue. Int J Mol Sci. 22(3):1221. .
• Shen M, Xu M, Zhong F, Crist MC, Prior A, Yang K, Allaire DM, Choueiry F, Zhu J, Shi H (2021). A multi-omics study revealing the metabolic effects of estrogen in liver cancer cells HepG2. Cells. 10(2):455. .
• Krolick KN, Tapp DN, McMurray MS, Shi H (2021). Sex differences in feeding regulated by estrogen: crosstalk between dopaminergic reward circuitry and adiposity signals. In: . Chapter 12. Editor: Qingchun Tong. CRC Press, Taylor & Francis Group. ISBN 9780367420291.
• Xu M, Wang C, Krolick KN, Shi H, Zhu J (2020). Difference in post-stress recovery of the gut microbiome and its altered metabolism after chronic adolescent stress in rats. Sci Rep. 10(1):3950. .
• Zhu Q, Weng J, Shen M, Fish J, Shen Z, Coschigano KT, Davidson WS, Tso P, Shi H, Lo CC (2020). Apolipoprotein A-IV enhances fatty acid uptake by adipose tissues of male mice via sympathetic activation. Endocrinology. .
• Wang Q, Sharma VP, Shen H, Xiao Y, Zhu Q, Xiong X, Guo L, Jiang L, Ohta K, Li S, Shi H, Rui L, Lin JD (2019).  The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation. Nat Metab. .
• Pence S, Zhu Q, Binne E, Liu M, Shi H, Lo CC (2019). Reduced diet-induced thermogenesis in apolipoprotein A-IV deficient mice. Int J Mol Sci. 20(13). .
• Zhu Q, Glazier BJ, Hinkel BC, Cao J, Liu L, Liang C, Shi H (2019). Neuroendocrine regulation of energy metabolism involving different types of adipose tissues. Int J Mol Sci. 20(11). .
• Zhu Q, Liu X, Glazier BJ, Krolick KN, Yang S, He J, Lo CC, Shi H (2019). Differential sympathetic activation of adipose tissues by brain-derived neurotrophic factor. Biomolecules. 9(9). .
• Krolick KN, Zhu Q, Shi H (2018). Effects of estrogen on central nervous system neurotransmission: implication for sex differences in mental disorders. Prog Mol Biol Transl Sci. 160:105-171. 
• Shen M, Cao J, Shi H (2018). Effects of estrogen and estrogen receptors on transcriptomes of HepG2 cells: a preliminary study using RNA sequencing. Int J Endocrinol. 2018:5789127. .
• Cao J, Zhu Q, Liu L, Glazier BJ, Hinkel BC, Liang C, Shi H (2018). Global transcriptome analysis of brown adipose tissue of diet-induced obese mice. Int J Mol Sci. 19(4). .

Courses Taught

• Human physiology (BIO 305)
• Endocrinology (BIO 454/554)
• Undergraduate seminar (BIO 490)
• Graduate seminar (BIO 710)
• Independent study (BIO 177, 277, 320, 340, 377, 620, etc)